Aims of ProCeDE

To investigate the performance of the new ESPGHAN diagnostic criteria for CD in practice in different european countries. 

 

Primary aim:

  • To evaluate whether the omission of biopsies in selected pediatric cases does result in certain diagnosis of CD (avoid false positive diagnosis of CD)

 

Secondary aims:

  • To evaluate characteristics and severity of symptoms in relation to histology and CD specific antibody titers
  • To determine the best optimal cut-off point for antibody levels in children with symptoms of CD which predict mucosal damage with 99% specificity.
  • To determine whether the determination of HLA typing adds diagnostic value in cases with positive specific antibodies
  • To determine which of the available antibody tests (TG2, EMA, DGP) are most suitable for the initial diagnosis in relation to age and type of symptoms
  • To determine which of the available antibody tests (TG2, EMA, DGP) are most suitable for follow up of the children with proven CD during the 18 months on a gluten free diet (GFD)
  • To evaluate prospectively whether a diagnostic score based on symptoms, histology, serology and HLA testing is most appropriate
  • To evaluate the inter observer variability for histology between the local and the reference pathologist